Evaluation of the antioxidant and hepatoprotective activity of Mucuna pruriens (L) cv. utilis forage meal and their polyphenols extract in Sprague Dowley rats
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Abstract
period (30d), the animals were slaughtered and biochemical blood indicators were studied, the alanine aminotransferase (ALT) and the aspartate aminotransferase (AST) enzymes were quantified. The activity of the catalase antioxidant enzyme and the antioxidant state of the animals were also determined. The increase of the catalase enzyme concentration in liver (10.42 UI/L) and blood serum (20.50 UI/L) showed that the meal and their extract change the redox state caused by the CCl4.The forage meal and their polyphenols extract showed its hepatoprotective effect against the damage action of the CCl4,evaluated by the alanine aminotransferase and aspartate aminotransferase. The results showed that it is possible to use, in diets for rats the forage meal and their polyphenols extract with antioxidants effects similar to those of the control diet, which used synthetic antioxidants, vitamins and minerals. It is suggested to developed similar studies in productive animals, that includes studies of doses optimization for different animal categories.
Key words: oxidative stress, serum polyphenols, catalase, aspartate aminotransferase.
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